*Also visit KMS Hospital
background

Services

Formulation Development
Solid Oral

KMS Pharma develop generic products in oral formulations which are solids, liquids and sterile formulations. A team of scientists are available, who are expertise in developing different platform technologies. We provide service to formulations completely from sourcing or raw materials, to other stages like pre-formulation, design of experiments per QbD, stability studies per ICH guidance’s, drug excipient compatibility, pilot scale process development.

We also cater to design process which are typical wet granulation, dry granulation, wurster, top spray granulation, extrusion and spheronization, multilayer compression, functional and non-functional coating on pellets and tablets, capsule filling etc. Formulation development lab has stability chambers to cater the global requirement per ICH.

Semisolid Products

KMS Pharma currently initiated development focus is on semisolid products. KMS Pharma is capable of developing semisolid dosage forms for topical application, which are novel and non- infringing. Dosage form such as ointments, emulsions, gels, pastes, suppositories are few which can be developed at KMS. KMS Pharma have experience in sourcing uncommon excipients used for the semisolid formulations. KMS Pharma also develop method for preservative efficacy testing. KMS Pharma does develop container closure for moisture vapor transmission rate studies for various combination of containers and closure systems, which are

 Laboratory experience preparing a wide variety of formulation base types.
 Sourcing uncommon excipients.
 Scale-up experience, from small batch volumes (≤ 100mL) to ≥ 1L.
 Establishment of preservative efficacy in prototype formulations.
 Assessment of prototype formulations in a thermal stability program.
 Development of analytical methods including extraction methods and HPLC-based methods for        drug concentration and purity.

Liquid Oral Products

KMS Pharma also into formulation of liquid oral dosage form, which are imperative for patients of pediatric and geriatric category. KMS Pharma is capable of developing both monophasic (clear solution) and biphasic (suspension or emulsion). Analytical team and process team is expertise in development of liquid oral with one or more active in the formulation. Formulation are designed to cater the patient needs which are sugar based for general population and non-syrup based for geriatric/diabetic patient. Throughout the development scale up and commercial, focus is made to make a physical and chemically stable, palatable and presentable formulation complying to global requirement. Container closure is integral part of the development to ensure flawless technology transfer.

KMS Pharma develop generic products in oral formulations which are solids, liquids and sterile formulations. A team of scientists are available, who are expertise in developing different platform technologies. We provide service to formulations completely from sourcing or raw materials, to other stages like pre-formulation, design of experiments per QbD, stability studies per ICH guidance’s, drug excipient compatibility, pilot scale process development. We also cater to design process which are typical wet granulation, dry granulation, wurster, top spray granulation, extrusion and spheronization, multilayer compression, functional and non-functional coating on pellets and tablets, capsule filling etc. Formulation development lab has stability chambers to cater the global requirement per ICH.

Sterile Products

KMS Pharma has the right equipment, facilities and highly dedicated formulation development specialists to help you arrive at the optimal dosage form for your API and application. We ensure any forms we develop are scalable, compliant and marketable for our customers. We adopt a comprehensive, time-bound strategy in developing stable products that are efficient in all quality aspects. Our formulation development team enables small amounts of drug product materials to be developed using experimental design methodologies supported by testing at every stage with key performance analytics .

We work on our formulation development strategy based on in-depth study of patents, scientific literature, compendia information, critical quality attributes (CQA) and quality target product profiles (QTPP) of the respective drug delivery system and nature of the molecule.

We develop optimized processes that ensure smooth commercial manufacturing. We are sensitive in utilising the client investments/budgets to deliver a cost-effective solution for their formulation development needs. We help pharmaceutical companies to successfully resolve their challenging pharmaceutical compounds both in early-phase formulation development and as well as full generic development.

KMS Pharma capability to develop various from of sterile products start from aqueous injection, Non-Aqueous injection, Micro emulsion, Nano Emulsion, Nano suspension, Lyophilised products, Pre-Filled syringe, Infusion Bags, Ophthalmic solution, Ophthalmic emulsion, Ophthalmic suspension, Macro suspension, Microsphere, Liposome and powder for solution for injection.

Apart from general chemical molecule KMS Pharma can also able to handle Non-Beta Lactam based products, Atypical B-lactams (Imipenem, Entrapenam, Meropenam), Protein and peptide based products, Anti-cancer products, Hormone based Products.

KMS Pharma has expertise in development of Bio-Similar Injection, 505 (b)(2) sterile Products and NCE clinical formulation development

Formulation Development

LIST OF EQUIPMENTS

KMS Pharma is a DSIR approved & ISO certified company established in 2011 at Chennai, Tamilnadu, India.

 Fluid Bed Dryer – Retsch
 Encapsulation machine, MF 300
 Tablet coating machine
  • Conventional coating pan, ideal cure
  • Auto coating machine, Neocota
 High pressure Homogeniser, GEA Niro Soavi- Panda Plus
 Blister pack machine
 Mechtek (Ezee blist)
 Oscillating Granulator-Anchor mark
 Moisture analyser- Mettler Toledo
 Tap density apparatus, Electrolab
 Disintegration tester, Electrolab
 Hardness Tester, Lab India
 Induction cap sealing machine,sealers india agencies
 Rotary compression machines
  • Cadmach 17 station “D”, “B” tooling
  • Karnavati 10 station “D”, “B” tooling
 Low shear blender
  • Octagonal blender – 3L,7L
  • Double cone blender – 3L,5L
 Roll compactor -CIP
 Multi Mill, bectochem
 Fluid Bed Processor (FBP) with Top & wurster column – ACG
 Lab scale homogeniser
 Sieve shaker- Electrolab
 Vibratory sifter, Bectochem
 Extruder & spheronizer, Fuji Paudal